Jeanne Palmer, MD, Mayo Clinic, Phoenix, AZ, discusses the role of allogeneic stem cell transplantation (alloSCT) in the treatment of myelofibrosis (MF), highlighting important factors to consider when selecting patients for transplant. Dr Palmer then comments on donor selection, and further explains various methods that may be followed to manage splenomegaly. To conclude, Dr Palmer shares some insights into how novel therapies may affect the role and timing of transplant in MF. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.