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IWWM-11 2022 | The efficacy of zanubrutinib versus ibrutinib in patients with WM harboring various mutations

Constantine Tam, MBBS (Hons), MD, FRACP, FRCPA, Alfred Health, Monash University, Melbourne, Australia, shares some results from a genomic analysis of the ASPEN study (NCT03053440), which evaluated the efficacy of zanubrutinib versus ibrutinib in patients with Waldenström’s macroglobulinemia (WM). Results from this analysis suggest that zanubrutinib may demonstrate higher efficacy in patients with various mutations, including CXCR4 and TP53 mutations. This interview took place at the 11th International Workshop on Waldenström’s Macroglobulinemia (IWWM-11), held in Madrid, Spain.

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