Deepa Jagadeesh, MD, PhD, Case Comprehensive Cancer Center, Cleveland, OH, gives an overview of the current treatment landscape for patients with T-cell lymphomas. For patients who are CD30-positive, Dr Jagadeesh highlights the use of brentuximab vedotin plus CHOP, which was approved based on the results of the ECHELON-2 trial (NCT01777152). For CD30-negative patients, Dr Jagadeesh reports the use of CHOP-based regimens, and in patients over 60, comments on the addition of etoposide to the treatment regimen. In the relapsed/refractory setting, single agent approaches are typically used. Finally, Dr Jagadeesh comments on the role of transplantation for patients with T-cell lymphomas. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.