ASH 2022 | Results from the randomized Phase III DaunoDouble trial
Christoph Röllig, MD, MSc, Dresden University of Technology, Dresden, Germany, comments on the results from the Phase III DaunoDouble trial (NCT02140242), which sought to answer two key questions in newly diagnosed acute myeloid leukemia (AML). The trial demonstrated that 60mg of daunorubicin is the optimal dose at first induction, as there was no difference in early responses, complete response (CR) rates, or overall survival (OS) between patients receiving 60mg or 90mg. Moreover, in those with good responses to the first cycle of induction, a second induction is not necessary, as it provided no significant benefit in CR or OS rates. This interview took place at the 64th ASH Annual Meeting and Exposition congress held in New Orleans, LA.
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Disclosures
BMS: Consultancy, Honoraria; Amgen: Honoraria; AbbVie: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Honoraria; Novartis: Consultancy, Honoraria, Research Funding; Servier: Consultancy; Jazz: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria, Research Funding; Roche: Consultancy, Honoraria.
