Nicholas Short, MD, University of Texas MD Anderson Cancer Center, Houston, TX, shares the results of a Phase I/II study (NCT03576547) of combined ponatinib, venetoclax, and dexamethasone in relapsed/refractory (R/R) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Pre-clinical studies have shown synergy of the combination, and Dr Short highlights that the regimen is entirely oral. So far, the results suggest that the chemotherapy-free regimen is safe and shows promising efficacy with durable responses in a heavily pretreated population. This interview took place during the 2021 European School of Hematology (ESH) 2nd Translational Research Conference on Acute Lymphoblastic Leukemia.