ASH 2023 | ViPOR: a multi-targeted therapy for the treatment of R/R DLBCL
Christopher Melani, MD, National Institutes of Health, Bethesda, MD, discusses a Phase Ib/II study (NCT03223610) investigating the use of ViPOR, a 5-drug combination regimen, for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). This multi-targeted therapy combines venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide. All agents were administered for a fixed duration in non-continuous cycles during the study. The ViPOR therapeutic approach was well tolerated and resulted in deep and durable remissions, with potential for cure, in 38-47% of patients, depending on the disease subtype. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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