Stephan Grupp, MD, PhD, Children’s Hospital of Philadelphia, Philadelphia, PA, shares his opinion on what should now be the focus of CAR-T research in acute lymphoblastic leukemia (ALL). Dr Grupp highlights the need for longer follow-ups, extending the reach of CAR-T therapies, and improvements in manufacturing. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.