What leads to shorter progression-free survival in CLL patients?

Clare Sun

Clare Sun, MD from the National Heart, Lung, and Blood Institute, Bethesda, MD provides an overview on the progression of ibrutinib treatment in chronic lymphocytic leukemia patients with somatic mutations at the International Workshop for Chronic Lymphocytic Leukemia (iwCLL) 2017 in New York, NY. Dr Sun has focussed on patients on ibrutinib, looking specifically at mutations in the B-cell receptor and NF-kB pathways which can predict clinical outcomes in patients. Shorter progression-free survival (PFS) is thought to be due to greater genomic instability which is dependent on the quantity of mutations. Dr Sun’s data represents the preliminary stage of her study of patients on ibrutinib. Her hope is to follow patients over a longer period to see if mutations change over time, and to determine which patients have shorter PFS requiring alternative therapies.

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