Clare Sun, MD, National Institutes of Health, Bethesda, MD, outlines supportive care strategies for patients with chronic lymphocytic leukemia (CLL) who experience immune-related complications including infections and autoimmune cytopenias. Dr Sun explains that immunoglobulin replacement therapy (IRT), as well as antimicrobial and antiviral prophylaxis, and vaccination can be given to minimize the risk of infections. In addition, patients treated with venetoclax may require growth factor support to prevent severe febrile neutropenia, and patients who experience autoimmune cytopenia should be treated with immunosuppressive therapies. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.
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