So CD30 is universally expressed in Hodgkin Lymphoma and has minimal expression in normal tissue, which makes it a really promising target for CAR-Ts. Previous clinical trials have shown that CD30-directed CAR-Ts have high response rates in patients with Hodgkin Lymphoma. Even patients who have been refractory to multiple lines of therapy, including brentuximab vedotin and checkpoint inhibitors...
So CD30 is universally expressed in Hodgkin Lymphoma and has minimal expression in normal tissue, which makes it a really promising target for CAR-Ts. Previous clinical trials have shown that CD30-directed CAR-Ts have high response rates in patients with Hodgkin Lymphoma. Even patients who have been refractory to multiple lines of therapy, including brentuximab vedotin and checkpoint inhibitors. So, CD30 CAR-Ts are very promising target for Hodgkin Lymphoma and can treat patients with really refractory disease.
The main challenges now are that we have really high response rates, but a lot of patients still relapse, with the majority of patients still relapsing at one year. So we still need to improve the durability of responses. And of course, there’s also some patients who are not responding to CD30 CAR-Ts. So this is a really promising treatment, which has low toxicity, very tolerable for patients with low cytokine release syndrome and no neurotoxicity, but we still need to improve on the durability of responses for these patients.