ASCO 2023 | Accelerated-phase MPNs: pathophysiology, treatment approaches and ongoing clinical trials
Anand Patel, MD, University of Chicago, Chicago, IL, discusses a recently published review on accelerated phase (AP) or blast phase (BP) myeloproliferative neoplasms (MPNs). Dr Patel summarizes the clinical and molecular risk factors for MPN progression and discusses conventional treatment approaches, such as intensive chemotherapy, hypomethylating agent (HMA)-based therapy, and HMA-venetoclax combination therapy. Additionally, Dr Patel discusses strategies being explored for patients with ASXL1-mutated disease, TP53-mutated disease, and IDH-mutated disease, including magrolimab and IDH inhibitors. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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