Shebli Atrash, MD, Levine Cancer Institute & Atrium Health, Charlotte, NC, discusses the results of a Phase I trial (NCT04822337) evaluating belantamab mafodotin in combination with carfilzomib, lenalidomide, and dexamethasone (KRd) for the treatment of multiple myeloma (MM) after 1-3 prior lines of therapy. As the results were promising, this combination will move into Phase II testing. Dr Atrash also briefly comments on how the addition of belantamab mafodotin may benefit patients with high-risk disease and how the use of BCMA-targeting therapies in the frontline may impact subsequent therapy following relapse. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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