Antonio Cuneo, MD, St. Anna University Hospital, Ferrara, Italy, explains the importance of real-world data (RWD) in chronic lymphocytic leukemia (CLL), commenting on the issue of selection bias in clinical trials. Dr Cuneo explains that real-world studies evaluating the safety and efficacy of BTK and Bcl-2 inhibitors in CLL patients demonstrated similar results to those reported in clinical trials, although there was a higher BTK inhibitor discontinuation rate probably due to a higher comorbidity burden in the real-world CLL population. This interview took place at the 2022 European Research Initiative on CLL (ERIC) Meeting.
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