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ASCAT 2024 | Hydroxyurea and follicular density in females with SCD, and the importance of fertility preservation
Jean-Hugues Dalle, MD, PhD, Université Paris Cité, Paris, France, discusses data on the impact of hydroxyurea treatment on follicular density in female patients with sickle cell disease (SCD). Prof. Dalle also emphasizes the importance of fertility preservation before transplantation, especially for prepubescent females, recommending ovarian tissue cryopreservation due to the success of reimplantation in inducing pregnancies. For post-pubescent patients, secondary follicle preservation is suggested, but hormonal stimulation poses risks due to potential thrombotic complications. This interview took place at the 19th Annual Scientific Conference of the Academy for Sickle Cell and Thalassaemia (ASCAT 2024) in London, UK.
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Transcript
We recently published data regarding follicular density in female patients who received hydroxyurea. And yes, there are some changes with hydroxyurea regarding the primary follicle or the secondary one. I don’t remember, I’m sorry. Yes, there are some consequences of hydroxyurea regarding the follicular density outside the transplant procedure. For those patients who will receive transplantation, it’s mandatory today to propose fertility cryopreservation before transplantation because these are some useful techniques with results...
We recently published data regarding follicular density in female patients who received hydroxyurea. And yes, there are some changes with hydroxyurea regarding the primary follicle or the secondary one. I don’t remember, I’m sorry. Yes, there are some consequences of hydroxyurea regarding the follicular density outside the transplant procedure. For those patients who will receive transplantation, it’s mandatory today to propose fertility cryopreservation before transplantation because these are some useful techniques with results. Then if you avoid to propose fertility preservation, you missed your consular role. And for female patients before puberty, you have to propose ovarian tissue cryopreservation. We know currently that it works – reimplantation of ovarian tissue post-transplant, years post-transplant may induce pregnancies and it works. Then you have to…for female patients post-puberty you may propose secondary follicle preservation after stimulation but you have to keep in mind hormonal stimulation is a danger in patients with thrombotic risk then it’s not so easy to propose in sickle cell disease patient stimulation. Probably it’s safer in thalassemia patients.
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Disclosures
Advisory board: Vertex.
