Jean-Hugues Dalle, MD, PhD, Université Paris Cité, Paris, France, discusses the challenges in preventing acute toxicity in pediatric patients undergoing myeloablative conditioning regimens, particularly those using busulfan. While preventive measures are limited, Prof. Dalle emphasizes the importance of considering factors like nutritional status and hemoglobin levels before transplantation and having thorough discussions with families about the risks to mentally prepare them for the transplant journey. This interview took place at the 19th Annual Scientific Conference of the Academy for Sickle Cell and Thalassaemia (ASCAT 2024) in London, UK.
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