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SOHO 2022 | OPTIC post hoc analyses: OPTIC and PACE comparison & impact of mutations on ponatinib starting dose

Jorge Cortes, MD, Augusta University, Augusta, GA, comments on some of the results of post-hoc analyses of the OPTIC trial (NCT02467270) which evaluated a response-based dosing regimen of ponatinib in patients with resistant or intolerant chronic myeloid leukemia in the chronic phase (CP-CML). A post-hoc analysis comparing the OPTIC study with the PACE study (NCT01207440) showed that dose adjustments led to a decrease in the incidence of arterial occlusive events without impacting treatment efficacy. In addition, another study demonstrated that patients with specific mutations may respond better to a 45 mg starting dose instead of 30 mg. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.

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