Jean-Philippe Merlio, MD, PhD, Tumor Biology and Tumor Bank, CHU Bordeaux, Pessac, France, discusses the diagnosis of cutaneous B-cell lymphoma (CBCL), commenting on the particular significance of early diagnosis for large cell lymphomas. Prof. Merlio also talks on the importance of accurate diagnosis in the treatment of large B-cell lymphomas, highlighting the use of systemic therapy, rituximab and radiation therapy. This interview took place at the EORTC Cutaneous Lymphoma Group 20-21 meeting in Marseille.