Sarah Tasian, MD, Children’s Hospital of Philadelphia, Philadelphia, PA, provides an overview of remaining barriers in treating pediatric leukemias. Conventional chemotherapy is the standard of care in pediatric patients, and establishing the correct dose whilst minimizing toxicity is an important issue for healthcare practitioners. Dr Tasian additionally highlights the development of immunotherapies for pediatric patients who have relapsed from frontline chemotherapy. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.