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IMS 2024 | CMV reactivation during treatment with bispecifics for R/R myeloma

Eric Jurgens, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the prevalence of infections, particularly cytomegalovirus (CMV) reactivation, in patients with relapsed/refractory (R/R) multiple myeloma (MM) receiving bispecific antibody therapy. A single-center retrospective study demonstrated that 49% of patients exhibited detectable CMV, and 39% met the criteria for CMV reactivation. Despite this high rate, only a few patients required treatment, and no baseline characteristics or immune cell counts appeared to predict reactivation. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.

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