Naveen Pemmaraju, MD, University of Texas MD Anderson Cancer Center, Houston, TX, outlines the details of an in-progress trial (NCT04354727) of pelcitoclax (APG-1252) as a single agent or in combination with ruxolitinib, a JAK2 inhibitor, in myelofibrosis (MF) patients. APG-1252 is a BCL-2/BCL-xL dual inhibitor. It is theorized that JAK2 mutant cells are dependent on BCL-2/BCL-xL to survive, so the combination of BCL and JAK2 inhibition could overcome resistance to JAK2 inhibitors and augment clinical responses. A standard 3+3 dose-escalation design will be employed to determine safety and efficacy of the monotherapy and treatment combination. APG-1252 plus ruxolitinib treatment will begin once the maximum tolerated dose for APG-1252 single-agent treatment has been determined in part 1 of the trial. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.