Zaid Abdel Rahman, MD, Mayo Clinic, Jacksonville, FL, discusses highlights from the American Society of Clinical Oncology (ASCO) 2021 Virtual meeting, including the results of a study evaluating chemotherapy-free regimens in Philadelphia positive acute lymphoblastic leukemia (ALL), as well as the findings from the ZUMA-3 trial (NCT02614066), also in ALL. In addition, Dr Rahman talks on the results of a study comparing the use of acalabrutinib versus ibrutinib in previously treated patients with chronic lymphocytic leukemia (CLL). This interview was conducted at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.