Paolo Ghia, MD, of the Università Vita-Salute San Raffaele, Milan, Italy, explores highlights from EHA 2020, including the CLL14 trial (NCT02242942) investigating venetoclax-obinutuzumab in previously untreated, comorbid, chronic lymphocytic leukemia (CLL). The CAPTIVATE study (NCT02910583), which investigated measurable residual disease (MRD)-guided discontinuation and fixed duration therapy with the combination of ibrutinib and venetoclax is also discussed. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).