John Allan, MD, Weill Cornell Medicine, New York, NY, discusses the future of chronic lymphocytic leukemia (CLL) treatment, drawing focus on the excitement around moving towards fixed-duration, chemotherapy-free oral regimens and novel agents. Dr Allan also mentions the promise of Bruton’s tyrosine kinase (BTK) inhibitors and BCL-2 inhibitors in the future of CLL treatment, and the importance of tailoring therapies based on a patient’s risk factors, comorbidities and disease biology. This interview took place during the 2nd ESH Translational Research Conference on Chronic Lymphocytic Leukemia (ESH CLL), 2022.