Viola Poeschel, MD, of the Saarland University Medical School, Homburg, Germany, discusses the results of the Phase III FLYER study (NCT00278421), from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA. This revealed that 4 cycles of CHOP plus 6 applications of rituximab to young, favorable-prognosis diffuse large B-cell lymphoma patients was non-inferior to the standard of 6 cycles of CHOP and 2 applications of rituximab; sparing the need for excessive chemotherapy. Dr Poeschel also discusses further research in this area.