Angela Dispenzieri, MD, of the Mayo Clinic College of Medicine, Rochester, MN, discusses the use of daratumumab for amyloid light-chain (AL) amyloidosis and clinical trials evaluating its use. Specifically highlighted is the ANDROMEDA study (NCT03201965), as well as prospective trials in the relapsed/refractory setting. This interview was recorded via an online conference call with the Video Journal of Hematological Oncology (VJHemOnc).