Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, describes when and how to use ibrutinib for the treatment of chronic lymphocytic leukemia (CLL) at the 24th Congress of the European Hematology Association (EHA) 2019, held in Amsterdam, Netherlands. Dr Scarfo goes on to give her thoughts on the long-term, real-world data available for ibrutinib.