Rafael Bejar, MD, PhD, UC San Diego Moores Cancer Center, San Diego, CA, discusses the clinical implications of clonal hematopoiesis in the cancer setting. Specifically, he focuses on therapy-related myeloid neoplasms and potential strategies to counter clonal expansion. This interview took place at the 2nd Regional Symposium on Myelodysplastic Syndromes (MDS 2020), held in Tel Aviv, Israel.