Daniel Pollyea, MD, MS, of the University of Colorado, Denver, CO, outlines the use of venetoclax, a BCL-2 inhibitor, in acute myeloid leukemia (AML) and caveats associated with its use, including moving this treatment beyond its approved indication in unfit, relapsed/refractory AML. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).