Peter Borchmann, MD, University Hospital Cologne, Cologne, Germany, discusses the applications of PET-CT in the prognosis and management of Hodgkin lymphoma (HL). Prof. Borchmann comments on how using PET allows for treatment personalization, and how total metabolic tumor volume (MTV) determination using PET is highly prognostic of patient outcomes. Moreover, the Phase III HD17 and HD18 trials (NCT01356680, NCT00515554) are discussed. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.