Prapti Patel, MD, University of Texas Southwestern Medical Center, Dallas, TX, gives an overview on therapy sequencing in acute myeloid leukemia (AML), and mentions the importance of the clinical data that is currently available, such as from the VIALE-A and VIALE-C trials (NCT02993523, NCT03069352). Dr Patel then mentions the importance of focusing on the biology of disease to better understand how to develop novel therapies in the future. This interview took place at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.