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EBMT 2024 | Do all patients require maintenance therapy following alloSCT?

Mark Levis, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, summarizes his talk on drug maintenance strategies post-allogeneic stem cell transplant (alloSCT) in patients with hematological malignancies. Dr Levis challenges the assumption that post-transplant maintenance is needed for all patients, as data in Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML) do not support this notion. The MORPHO study (NCT02997202) elucidated that not all patients with FLT3-mutant acute myeloid leukemia (AML) benefit from maintenance, but those who do can be identified using a FLT3-ITD measurable residual disease (MRD) assay. This interview took place at the 50th Annual Meeting of the EBMT in Glasgow, Scotland.

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Consultant: Astellas, Daiichi Sankyo, Novartis.