Could checkpoint inhibitors be the future of cutaneous T-cell lymphoma (CTCL) therapy? This exciting prospect is explored here by Christiane Querfeld, MD, PhD, from City of Hope, Duarte, CA, at the European Organisation for the Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force (CLTF) 2018 Congress, held in St. Gallen, Switzerland. Dr Querfeld discusses the potential of checkpoint inhibitors for CTCL, and highlights the areas of further study required to optimize our utilization of these agents.