Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, introduces a Phase I dose-escalation study (NCT03547115) of the oral CDK9 inhibitor (CDK9i) voruciclib in patients with relapsed/refractory (R/R) B cell non-Hodgkin lymphoma (NHL) and acute myeloid leukemia (AML). The preliminary results demonstrate promising efficacy and tolerability, with no significant myelosuppression or dose-limiting toxicities (DLTs). The trial is now evaluating voruciclib in combination with venetoclax. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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