Sergio Giralt, MD, Memorial Sloan-Kettering Cancer Center, New York, NY, discusses a Phase I trial (NCT03925935) of allogeneic engineered endothelial cell therapy for lymphoma patients undergoing high-dose conditioning regimens and autologous hematopoietic cell transplantation (auto-HSCT). AB-205 is a first-in-human engineered cell-therapy of umbilical vein endothelial cells. As high-dose therapy is associated with severe regimen-related toxicities (SRRT), AB-205, shown to accelerate the recovery of vascular niches, is intended to reduce these toxicities. The initial results show that AB-205 appears to be safe and potentially effective, with few adverse events and reduced SRRT occurrence. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.