Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, gives an overview of the challenges associated with treating pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) and the promise of tagraxofusp for the treatment of these patients. This interview took place at the third annual Texas MPN Workshop (TMW) 2022, held in San Antonio, TX.