Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive myeloid malignancy with traditionally poor patient outcomes. In this video, Naveen Pemmaraju, MD, of The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the outcomes of adult patients with BPDCN who received hematopoietic stem cell transplantation (HSCT) following remission induction with tagraxofusp, a targeted therapy directed to CD123. This interview took place during the Transplantation & Cellular Therapy (TCT) 2021 Meetings.