Patients with acute lymphoblastic leukemia (ALL) who relapse following CD19-directed CAR-T therapy may be CD19-positive or CD19-negative, which can impact management of the disease. Nitin Jain, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the consequences, and potential methods of prevention, of resistance to CAR-T in patients with ALL. This interview took place at the Eleventh Annual Meeting of the Society of Hematologic Oncology (SOHO 2023) held in Houston, TX.
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