The Multiple Myeloma Channel is supported with funding from BMS (Gold) and Legend Biotech (Bronze).
VJHemOnc is an independent medical education platform. Supporters, including channel supporters, have no influence over the production of content. The levels of sponsorship listed are reflective of the amount of funding given to support the channel.
IMS 2024 | Whole genome sequencing of patients with myeloma with African ancestry
Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, discusses the research he and his team conducted to investigate possible genetic factors contributing to the observed three-fold higher incidence of multiple myeloma (MM) among people of African descent. Using whole genome sequencing (WGS) on cases from individuals of European and African origin, genomic features of myeloma were found to be largely consistent across groups. However, the genomes of patients of African origin appeared less complex, with lower APOBEC-mutational activity. This raises questions about whether genetic differences or structural societal factors, like environmental stressors, contribute to these disparities. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
