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EHA 2026 | When to suspect and test for paroxysmal nocturnal hemoglobinuria
Yasutaka Ueda, MD, PhD, Osaka University, Suita, Japan, discusses the clinical features that should prompt testing for paroxysmal nocturnal hemoglobinuria (PNH), including unexplained fatigue and Coombs-negative hemolytic anemia. He emphasizes the importance of flow cytometry for diagnosis and timely referral to specialist centers for optimal management. This interview took place at the 31st Congress of the European Hematology Association (EHA) in Stockholm, Sweden.
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Transcript
It’s important for local doctors to be aware of the disease, especially when patients complain about fatigue. Well, hemoglobinuria is a hallmark of diagnosis of PNH, but around 30% to 40% of patients come up with a symptom. So another point is that a hemorrhagic anemia is present, but a coma state is negative. Then in that kind of situation, you could think about testing PNH-type cells by flow cytometry...
It’s important for local doctors to be aware of the disease, especially when patients complain about fatigue. Well, hemoglobinuria is a hallmark of diagnosis of PNH, but around 30% to 40% of patients come up with a symptom. So another point is that a hemorrhagic anemia is present, but a coma state is negative. Then in that kind of situation, you could think about testing PNH-type cells by flow cytometry. Then, while you are suspicious of PNH, you could refer to the center where specialists of PNH are working.
This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.
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