ASH 2023 | The effect of ibrutinib dose-reduction on outcomes of patients with CLL/SLL: real-world evidence
Kerry Rogers, MD, The Ohio State University, Columbus, OH, comments on two real-world studies that compared disease progression, using time to next treatment (TTNT), to assess the impact of dose adjustment of ibrutinib on clinical outcomes of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in the first-line setting. A dose adjustment treatment strategy was not found to increase the risk of moving to the next line of treatment, meaning it is a feasible alternative to continuous standard dose treatment, allowing efficacy and safety to be balanced in patients who experience side effects. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: Loxo@Lilly, Pharmacyclics, AstraZeneca, Beigene, Janssen, Genentech, AbbVie; Research Funding: Novartis, Genentech, AbbVie.
