Umbilical cord blood transplantation has several advantages over adult unrelated transplantation. And they include first, that they are readily available for transplantation, that they allow a greater HLA-match disparity between the donor and the recipient, and also, they have demonstrated a lower relapse risk in higher risk patients with acute leukemia, including those with a minimal residual disease positive before the transplant...
Umbilical cord blood transplantation has several advantages over adult unrelated transplantation. And they include first, that they are readily available for transplantation, that they allow a greater HLA-match disparity between the donor and the recipient, and also, they have demonstrated a lower relapse risk in higher risk patients with acute leukemia, including those with a minimal residual disease positive before the transplant.
The major drawback of umbilical cord blood transplantation is the very delayed engraftment of umbilical cord blood cells. And this is due to the low progenitor cell content in the graft, and this results in a greater transplant-related mortality and morbidity, and also in a higher use of hospital resources.
We thought as one possibility to overcome these issues would be to use standard cord blood cells. And that’s what did in this omidubicel clinical trial comparing omidubicel, that is a three-week expanded CB unit in the presence of nicotinamide and other hematopoietic cytokines that allows a very high number of progenitor cells while retaining the differentiation capability of the cells and maintaining both the functionality and the phenotype of the stem cells.
And this is why we started this randomized Phase III clinical trial comparing omidubicel expanded cord blood cells with the standard of care cord blood transplantation.