EBMT 2024 | The relationship between the gut microbiome and GvHD

Ernst Holler • 19 Apr 2024

EBMT 2024

General

Ernst Holler, MD, University Hospital Regensburg, Regensburg, Germany, gives an overview of the relationship between the gut microbiome and graft-versus-host disease (GvHD). A loss of microbiome diversity, mainly due to broad-spectrum antibiotic use or damage to paneth cells, dysregulates immune cell function in the gut, leading to acute GvHD. This could be corrected through better antibiotic stewardship or with fecal microbiota transplantation (FMT). Prof. Holler also addresses the paradox of antibiotic use, which can be both beneficial and harmful in the context of GvHD. The relationship between the gut microbiome and GvHD is complex, and further research is required. This interview took place at the 50th Annual Meeting of the EBMT in Glasgow, Scotland.

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