Nicolas Martinez-Calle, MD, Nottingham University Hospitals NHS Trust, Nottingham, UK, outlines what he believes to be the most influential findings in chronic lymphocytic leukemia (CLL) research, specifically mentioning the use of IgHV mutational status in the personalization of CLL therapy This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.