Arnon Nagler, MD, Chaim Sheba Medical Center, Tel Aviv, Israel, discusses the relationship between HLA mismatching and graft-versus-leukemia (GvL) effect in haploidentical transplantation in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML). First, Prof. Nagler explains the correlation observed between graft-versus-host disease (GvHD) and GvL in sibling and unrelated transplantation. Following this, Prof. Nagler highlights the impact of measurable residual disease (MRD) and cytogenetic risk on the efficacy of haploidentical transplant, and recent studies in this space. This interview took place at The 4th Society of Hematologic Oncology (SOHO) Italy Annual Conference, held in Rome, Italy.
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