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ESH CML/MPN 2025 | Supporting the growing number of pregnant patients with MPNs
In this video, Martin Griesshammer, MD, Johannes Wesling Medical Center, Minden, Germany, discusses the management of pregnancy in patients with BCR::ABL1-negative myeloproliferative neoplasms (MPNs), noting that earlier diagnosis and the delaying of pregnancy to later life have resulted in a growing number of pregnant patients with these hematological malignancies. Prof. Griesshammer highlights the need to address patients’ questions around pregnancy and conception using data from over 1,000 reported pregnancies in essential thrombocythemia (ET) and around 300 in polycythemia vera (PV). This interview took place at the European School of Haematology (ESH) 4th How to Diagnose and Treat: CML/MPN meeting in Vienna, Austria.
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Transcript
Well, the management of pregnancy during the course of BCR::ABL1-negative MPN is an increasingly frequent problem, and this is mostly due to an earlier diagnosis of these MPN patients and this is due to the trend in modern societies towards delaying pregnancy until later life. So 10 to 15 years ago, MPN, BCR::ABL1-negative MPN was a disease of older patients, so the median age was around 55/60...
Well, the management of pregnancy during the course of BCR::ABL1-negative MPN is an increasingly frequent problem, and this is mostly due to an earlier diagnosis of these MPN patients and this is due to the trend in modern societies towards delaying pregnancy until later life. So 10 to 15 years ago, MPN, BCR::ABL1-negative MPN was a disease of older patients, so the median age was around 55/60. But due to these advances, it’s now earlier, 20 to 25 years earlier, so we have a lot of young patients now diagnosed with BCR::ABL1-negative MPN. And of course, they want to become pregnant, and they can. And this is now an increasingly frequent problem and question asked by our patients, and this has to be addressed. And we have now many, many data, especially in essential thrombocythemia; more than 1,000 pregnancies are reported in the literature, but also in polycythemia vera, we have an increasingly large number of pregnant patients, around 300. And with this experience, we advise the patients how to get pregnant, what are the problems, what are the circumstances to pay attention to, and what are the possible complications.
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