Jitka Malčíková, PhD, Masaryk University, Brno, Czech Republic, discusses her poster presentation on minor-clone TP53 mutations in chronic lymphocytic leukemia (CLL) patients entering first-line treatment including the clonal evolution and clinical impact of these mutations. This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.