Naveen Pemmaraju, MD, The University of Texas, MD Anderson Cancer Center, Houston, TX, discusses the challenges of treating blastic plasmacytoid dendritic cell neoplasm (BPDCN) and gives an overview of current treatment strategies. Dr Pemmaraju talks on the approval of tagraxofusp for the treatment of BPDCN and IMGN632, and the potential future role of a novel CD123 antibody-drug conjugate which is currently under investigation. Dr Pemmaraju also comments on the increased acknowledgement of central nervous system involvement in BPDCN which may shape the future of research in the field. This interview took place at the Texas MPN Workshop: Second Annual Workshop and Meeting in 2021.