Deepu Madduri, MD, Icahn School of Medicine at Mount Sinai, New York, NY, presents preliminary data from the ongoing Phase Ib/II CARTITUDE-1 study (NCT03548207) of ciltacabtagene autoleucel (cilta-cel), a B-cell maturation antigen-targeting chimeric antigen receptor (CAR) T-cell therapy product, in 97 patients with relapsed/refractory (R/R) multiple myeloma. The Phase Ib portion of the study indicated that cilta-cel had a manageable safety profile at the recommended Phase II dose of 0.75×10^6 CAR T-cells/kg. Results from the Phase II portion using this dose demonstrated that single treatment with cilta-cel yielded early, deep and durable responses in heavily pretreated patients with R/R multiple myeloma, with an overall response rate (ORR) of 97%, a stringent complete response (CR) rate of 67% and a median progression-free survival (PFS) of at least one year. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.