Tagraxofusp (SL-401) is an anti-CD123 therapy that is FDA-approved for the treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN). Here Naveen Pemmaraju, MD, MD Anderson Cancer Center, Houston, TX, outlines the results from a phase 1/2 trial of tagraxofusp for relapsed/refractory intermediate or high risk myelofibrosis (NCT02268253), a setting where this agent is also hoped to excel. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.