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ASH 2022 | Phase I study of ven/aza maintenance therapy following ven/FluBu2 RIC alloSCT in high-risk MDS/AML

Jacqueline Garcia, MD, Dana-Farber Cancer Institute, Boston, MA, shares the findings of a Phase I trial assessing the safety and efficacy of venetoclax (ven)/azacitidine (aza) maintenance therapy following ven/fludarabine/busulfan (FluBu2) reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) in patients with high-risk acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS; NCT03613532). This trial aimed to address relapse risk after alloSCT in this high-risk patient population. Overall, ven/aza maintenance therapy appeared to be effective and well-tolerated, with low rates of infections and graft-versus-host disease (GvHD). This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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AbbVie, Astellas, and Takeda: Consultancy, Membership on an entity’s Board of Directors or advisory committees, Other: Advisory Board; AbbVie, Genentech, AstraZeneca, Prelude and Pfizer: Other: Clinical trial support (institutional); Research Funding; AbbVie: Research Funding.

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