Jacqueline Garcia, MD, Dana-Farber Cancer Institute, Boston, MA, shares the findings of a Phase I trial assessing the safety and efficacy of venetoclax (ven)/azacitidine (aza) maintenance therapy following ven/fludarabine/busulfan (FluBu2) reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) in patients with high-risk acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS; NCT03613532). This trial aimed to address relapse risk after alloSCT in this high-risk patient population. Overall, ven/aza maintenance therapy appeared to be effective and well-tolerated, with low rates of infections and graft-versus-host disease (GvHD). This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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